The Change Mariner

First Comprehensive Proteomic Analysis of Developing Animal

EurekAlert:

Carnegie Mellon University scientists have performed the first comprehensive proteome analysis of protein changes that occur in a developing animal, making surprising findings that could require scientists to revise standard thinking about how proteins orchestrate critical steps in embryonic development.

Their findings could one day provide a sensitive way to measure how drugs or environmental chemicals affect specific protein networks and harm development.

The research, reported online (http://dev.biologists.org/content/vol131/issue3/) and in the February 1 issue of Development, found that specific cells set to change shape during a key growth step are actually poised for their transformation far in advance and that many types of proteins are involved.
"Our findings counter long-held assumptions that a limited number of proteins are responsible for this step of development and that they become active right before the cells change shape," said Jonathan Minden, principal investigator on the study and associate professor of biological sciences at Carnegie Mellon University.

Posted by Bob King at March 30, 2004 03:39 PM | TrackBack
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